Thursday, November 3, 2016

Adderall & The Dangers of Dopamine Downregulation

As a college student, I know all too well what my peers and I alike think of this transitory period of our lives. This is a time where four years of our life are spent experimenting and are in essence, our formational years. Cycle upon cycle of hardcore studying, drinking, and experimentation are not unheard of. Many, doubtful of their own academic ability choose to indulge in a drug that is now notorious on college campuses everywhere: Adderall.

Prescribed most often for attention deficit hyperactivity disorder, Adderall is now one of the most often used drugs by college students who are desperately trying to study for their midterm and final examinations the night (and sometimes morning) before the test. Used responsibly or with a prescription, I don’t think Adderall is inherently detrimental. It’s when one is completely dependent on a substance that it can wreak havoc.

Casey Schwartz of The New York Times writes a great piece about Adderall addiction and the consequences that can unfold through substance abuse.

We know very little about what Adderall does over years of use, in and out of college, throughout all the experiences that constitute early adulthood. To date, there is almost no research on the long-term effects on humans of using Adderall. In a sense, then, we are the walking experiment, those of us around my age who first got involved with this drug in high school or college when it was suddenly everywhere and then did not manage to get off it for years afterward — if we got off it at all. We are living out what it might mean, both psychologically and neurologically, to take a powerful drug we do not need over long stretches of time. Sometimes I think of us as Generation Adderall.[1]

Adderall’s charm is that it makes you hyper-focused on the task at hand—especially and understandably useful when doing insane amounts of schoolwork. However, like any other controlled substance, it can do some major damage to your brain. Though I understand most people my age lack the foresight to be careful when using drugs, it’s imperative to know what you’re putting into your body and assess risk before you do anything even slightly questionable. Schwartz goes on to talk about the mechanisms behind Adderall addiction.

Amphetamines unleash dopamine along with norepinephrine, which rush through the brain’s synapses and increase levels of arousal, attention, vigilance and motivation. Dopamine, in fact, tends to feature in every experience that feels especially great, be it having sex or eating chocolate cake. It’s for this reason that dopamine is so heavily implicated in current models of addiction. As a person begins to overuse a substance, the brain — which craves homeostasis and fights for it — tries to compensate for all the extra dopamine by stripping out its own dopamine receptors. With the reduction of dopamine receptors, the person needs more and more of her favored substance to produce the euphoria it once offered her. The vanishing dopamine receptors also help explain the agony of withdrawal: Without that favored substance, a person is suddenly left with a brain whose capacity to experience reward is well below its natural levels1

The insidious side of Adderall dependence/addiction is hardly ever talked about and people need to be aware of the inherent risk they are taking when they over-indulge in study drugs or drugs in general. Ironically, when people get addicted to Adderall and don’t have access to their pills, some lose motivation and drive in school and by extension, life. In addition, those who are addicted talk about how they no longer have any passion or sense of reward after using Adderall for a number of years.

I could go on and on about this, but my point here is that drug addiction/withdrawal is not something to take lightly. It is very, very real and we as a society need to ascertain the risk vs. reward in using prescription stimulants and drugs as a whole. Just for the record, I am not some anti-drug far right asshole, but I do think it’s essential to be aware of the risk and take precautions in harm reduction. Doing well on a few exams isn’t worth binging on a drug that can destroy your dopamine receptors and suck the will to live out of you when used over a long period of time.

4 comments:

  1. You address a very important issue that is happening worldwide on college campuses. Adderall use isn’t as harmless as people make it out to be. How it got so accepted by mainstream society is so strange. It’s almost as if people forget that it’s similar to street meth in more ways than one. It’s vital that we teach people the risk behind these substances without being overly controlling. You can’t stop people from taking drugs, but you can prevent people from hurting themselves in the process. Risk aversion and drug management seems the best option for cases like these. It’s so ironic that a substance so well known for motivating people can lead to people being unmotivated and unhappy.

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  2. I agree that adderall use is dangerous. But all drugs are. Unfortunately, because this is prescribed, it may be easier to get if a student just goes into the doctor and lies. I know a few people who have done just that. Prescription medication addiction is skyrocketing and it's a shame that it's taken root in the most blossoming part of society: the college campus. The cult of perfection and busy is what rules college campuses across the country. Cramming for a test or paper, regurgitating it, then making room for the next stuff. I would like to put some of the blame of the institutions for making the process of learning such a living hell for students, leading some to resort to drugs to make the grade. Maybe if college wasn't so demanding, allowed for a little room to breathe, that would help. But it could also breed mediocrity so who knows.

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  3. The scariest thing about Adderall is how nonchalant and matter-of-fact students are about its use. I know many students that have become incapable of studying for a midterm without popping one, and around finals it seems like everyone is expected to be on Adderall 24/7. An overwhelming majority of these students have absolutely no need for it, and taking ADHD medication without consideration can only lead to developing a dependency and also making your brain unable to focus without it. Many students feel pressured to take it, as they are all competing wth each other and any advantage has to be taken to get ahead. Its a larger problem than people think, and it should really be banned and made unaccessible to people that don't have ADHD.

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  4. Adderall may be one of the most common "study aids" on campus but I also think we need to pay attention to the increasing use of Xanax on campuses. I was waiting before a class this year where we going to do presentations when one girl was talking to another about popping a Xanax to calm her down for this presentation. This is the same attitude that is taken in regards to Adderall, as if it is no big deal to be taking these drugs without medical clearance, just when the need is seen. I mean, just last year at USC a guy overdosed of Xanax.

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